Search results for "Lymphocyte graft engineering"

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Depletion of Alloreactive Donor T Lymphocytes by CD95-Mediated Activation-Induced Cell Death Retains Antileukemic, Antiviral, and Immunoregulatory T …

2007

In allogeneic hematopoietic stem cell transplantation (AHSCT) graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effect are closely but not invariably linked. Thus, harnessing donor lymphocyte mediated GVL immunity and separating it from GVHD is of particular interest. Based on results obtained in murine models we have explored the CD95-mediated activation-induced cell death (AICD) strategy to selectively deplete alloreactivity in human donor T lymphocytes in vitro. Following stimulation of CD3(+) T cells isolated from HLA-A* 0201-positive donors with HLA or minor histocompatibility antigen mismatched hematopoietic or nonhematopoietic cells in the presence of agonistic anti-CD…

AllodepletionLymphocyteApoptosisGraft vs Leukemia EffectHuman leukocyte antigenBiologyEpitopeLymphocyte DepletionImmune systemCell Line TumorMinor histocompatibility antigenmedicineCytotoxic T cellHumansTransplantation Homologousfas ReceptorTransplantationHematopoietic Stem Cell TransplantationFOXP3Hematologymedicine.anatomical_structureLymphocyte TransfusionImmunologyT cell depletionLymphocyte graft engineeringCD8Biology of Blood and Marrow Transplantation

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